Prolonged administration of proguanil induces reproductive toxicity in male rats
نویسندگان
چکیده
منابع مشابه
long-term administration of artesunate induces reproductive toxicity in male rats
background: artesunate is commonly used in malaria therapy. many antimalarial drugs have been associated with male reproductive dysfunction. the effect of artesunate on male reproductive activities was studied using in–vivo and in-vitro experimental models. methods: adult male rats (n=6) were orally given artesunate (2.9 mg/kg body weight) on daily basis for five days. artesunate (2.9 mg/kg bod...
متن کاملLong-Term Administration of Artesunate Induces Reproductive Toxicity in Male Rats
BACKGROUND Artesunate is commonly used in malaria therapy. Many antimalarial drugs have been associated with male reproductive dysfunction. The effect of artesunate on male reproductive activities was studied using in-vivo and in-vitro experimental models. METHODS Adult male rats (n=6) were orally given artesunate (2.9 mg/kg body weight) on daily basis for five days. Artesunate (2.9 mg/kg bod...
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متن کاملOral propylparaben administration to juvenile male Wistar rats did not induce toxicity in reproductive organs.
Parabens are in widespread use as preservatives in drugs. In the late 1990 s, concerns were raised about their capacity to disrupt endocrine function based on in vitro data and in vivo uterotrophic tests. Studies in juvenile male rats provided conflicting results on pospubertal sperm production. In an exploratory pharmacokinetic study, Wistar male rats received a single dose of propylparaben (P...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2011
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.36.587